General Information

  • ID:  hor000742
  • Uniprot ID:  Q4R5E9
  • Protein name:  Secretoneurin
  • Gene name:  SCG2
  • Organism:  Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
  • Family:  Chromogranin/secretogranin protein family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Macaca (genus), Cercopithecinae (subfamily), Cercopithecidae (family), Cercopithecoidea (superfamily), Catarrhini (parvorder), Simiiformes (infraorder), Haplorrhini (suborder), Primates (order), Euarchontoglires (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  GO:0005576 extracellular region; GO:0030141 secretory granule

Sequence Information

  • Sequence:  TNEIVEEQYTPQSLATLESVFQELGKLTGPNNQ
  • Length:  33
  • Propeptide:  MAEAKTHWLGAALSLIPLIFLISGAEAASFQRNQLLQKEPDLRLENVQKFPSPEMIRALEYIEKLRQQAHKEESSPDYNPYQGVSIPLQQKENGDESHLPERDSLSEEDWMRIILEALRQVENEPQSVPKENKPHALNSEKNFPIDMSDDYETQQWPERKLKHMQFPPMYEENSRDNPFKRTNEIVEEQYTPQSLATLESVFQELGKLTGPNNQKRERMDEEQKLYTDDEDDIYKANNIAYEDVVGGEDWNPVEEKIESQTQEEVRDSKENTEKNEQINDEVKRSGQLGIQEEDLRKESKDQLSDDVSKVITYLKRLVNAAGSGRLQNGQNGERATRLFEKPLDSQSIYQLIEISRNLQIPPEDLIEMLKTGEKPNGSVEPERELDLPVDLDDISEADLDHPDLFQNKMLSKSGYPKTVGRAGTEALPDGLSVEDILNLLGMESAANQKTSYFPNPYNQEKVLPRLPYGPGRSRSNQLPKAAWMPYVENRQMAYENLNDKDQELGEYLARMLVKYPEIINSNQVKRVPGQGSPEDDLQEEEQIEQAIKEHLNQGSSQETDKLAPVSKRFPVGPPKNDDTPNRQYLDEDLLTKVLEYLNQEKAEKGREHIAKRAMENM
  • Signal peptide:  MAEAKTHWLGAALSLIPLIFLISGAEA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Regulate the biogenesis of secretory granules
  • Mechanism:  Binds calcium with a low-affinity.
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-Q4R5E9-F1(AlphaFold_DB_ID)
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor000742_AF2.pdbhor000742_ESM.pdb

Physical Information

Mass: 424996 Formula: C160H253N41O58
Absent amino acids: CDHMRW Common amino acids: E
pI: 3.71 Basic residues: 1
Polar residues: 12 Hydrophobic residues: 9
Hydrophobicity: -69.39 Boman Index: -5955
Half-Life: 7.2 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 79.7
Instability Index: 4008.48 Extinction Coefficient cystines: 1490
Absorbance 280nm: 46.56

Literature

  • PubMed ID:  NA
  • Title:  NA